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Sea4Pain

Portuguese non-opioid for chronic pain
Investment overview
Impact category
Social economy
Investment type
Loan
Yearly interest
7.85
%
Term
6
months
Risk level
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Description
Impact
Financial viability
Promoter

What will you be financing?

Sea4Us is a biotechnology company dedicated to transform marine-inspired compounds into innovative therapies for unmet medical needs.

Sea4Us leverages the unique chemical compounds found in marine organisms to develop innovative treatments for chronic pain. Marine resources, such as sea sponges, provide a diverse array of bioactive molecules with the potential to target pain pathways. In the framework of its ‘Sea4Pain’ project, Sea4Us is transforming these marine-inspired compounds into optimised and synthesisable pharmaceutical ingredients. 

To take the development of Sea4Pain through to the first human trials and its licensing and marketing to the pharmaceutical industry, Sea4Us has launched Sea4Market, approved under the European Innovation Council's (EIC) Accelerator programme, representing a total investment of 5.9 million euros.

The funds raised through this campaign will be used to advance the second payment of the EIC Accelerator grant. The project will strengthen Sea4Us' operational capabilities and its readiness to obtain license agreements with pharmaceutical companies on a global level. 

Sea4Pain is a non-opiate analgesic for the treatment of moderate-severe chronic pain. This analgesic acts through a new mechanism of action, which allows for analgesic efficacy equivalent to opiates, but without altering sensory perception, without affecting the brain, and without the unwanted side effects of opiates. This drug, derived and refined from a molecule found in a marine sponge from the Portuguese cost, in Sagres, has proven its efficacy in cellular models and 6 different chronic disease models. The safety observed in the treatment makes it possible to offer a safe and effective alternative to existing pain treatments without the risk of addiction or habituation. This technology has been patented by Sea4Us in key international market regions.

The project will run for three years, starting on 1 March 2024 and ending on 28 February 2027. The main goal is to advance the development of Sea4Us' innovative medicines, particularly Sea4Pain, by financing key R&D activities such as regulated pre-clinical toxicology, clinical trial applications and the execution of first-in-human clinical trials. The project also has the support of the EIC-Fund to accelerate the commercialisation of the drug. 

You can learn more here: Sea4Us_Sea4Pain_.pdf

What is the impact?

Direct

Contribution to health through research and development of innovative treatments: with the funding, Sea4Us will continue the development of innovative treatments for chronic pain based on marine compounds. Based on research and development processes, the promoter has created a therapeutic drug from molecules found in a marine sponge, with high efficacy and no serious side effects. The promoter focuses on efficient production and development processes that allow for lower material losses and lower production costs, with the aim of keeping costs low and providing a product that is more accessible to patients.

Creation and maintenance of skilled jobs: the implementation phase to be funded by this campaign will result in one person being hired. Sea4Us, which currently has a team of 19 people, contributes to the creation of highly qualified jobs in the Algarve region of Portugal, with 18 highly qualified people, 10 of whom are PhDs.

Indirect

Promoting the quality of life of patients with chronic pain: through treatment with Sea4Pain, patients will be able to access an effective analgesic medication that reduces pain without adverse side effects and without the potential for addiction, representing an important and necessary alternative to the use of opioids. The non-opioid drugs in this solution provide pain relief and contribute to improving patients' quality of life. The commercialization of Sea4Pain will allow Sea4Us to reinvest in its production, developing new drugs for other pressing clinical needs, and delivering treatments that impact people's lives.

Contribution to the maintenance of marine ecosystems and sustainable marine economic activities: the promoter's central purpose is the protection and maintenance of marine resources, carrying out ecosystem monitoring, recording and managing invasive species, and contributing to the repopulation of native species. Sea4Us is a voluntary signatory of the UN Global Compact, a member of the European Animal Research Association and prioritizes transparency and ethics in its processes.

Promoting the economic and scientific development of the Algarve and Portugal: Sea4Us has its laboratory in Sagres, in the Algarve, where biotechnology activities are carried out, mobilizing a network of dozens of active partners to implement projects and disseminate knowledge in this region of Portugal. In this way, it is possible to raise the potential of the country's marine resources and the development of differentiating activities in the blue economy to an international scale, contributing to local economic development. In addition, through partnerships with universities, it contributes to the advancement of scientific knowledge, having collaborated on seven master's theses already completed at the company, two doctoral theses completed and another five in progress.

Impact indicators

CO2 avoided per year
clean energy
1
created by our projects
of sustainable
impacted

Contribution to the Sustainable Development Goals

About the Promoter

About
SEA4US, BIOTECNOLOGIA E RECURSOS MARINHOS, S.A.

Direct

Contribution to health through research and development of innovative treatments: with the funding, Sea4Us will continue the development of innovative treatments for chronic pain based on marine compounds. Based on research and development processes, the promoter has created a therapeutic drug from molecules found in a marine sponge, with high efficacy and no serious side effects. The promoter focuses on efficient production and development processes that allow for lower material losses and lower production costs, with the aim of keeping costs low and providing a product that is more accessible to patients.

Creation and maintenance of skilled jobs: the implementation phase to be funded by this campaign will result in one person being hired. Sea4Us, which currently has a team of 19 people, contributes to the creation of highly qualified jobs in the Algarve region of Portugal, with 18 highly qualified people, 10 of whom are PhDs.

Indirect

Promoting the quality of life of patients with chronic pain: through treatment with Sea4Pain, patients will be able to access an effective analgesic medication that reduces pain without adverse side effects and without the potential for addiction, representing an important and necessary alternative to the use of opioids. The non-opioid drugs in this solution provide pain relief and contribute to improving patients' quality of life. The commercialization of Sea4Pain will allow Sea4Us to reinvest in its production, developing new drugs for other pressing clinical needs, and delivering treatments that impact people's lives.

Contribution to the maintenance of marine ecosystems and sustainable marine economic activities: the promoter's central purpose is the protection and maintenance of marine resources, carrying out ecosystem monitoring, recording and managing invasive species, and contributing to the repopulation of native species. Sea4Us is a voluntary signatory of the UN Global Compact, a member of the European Animal Research Association and prioritizes transparency and ethics in its processes.

Promoting the economic and scientific development of the Algarve and Portugal: Sea4Us has its laboratory in Sagres, in the Algarve, where biotechnology activities are carried out, mobilizing a network of dozens of active partners to implement projects and disseminate knowledge in this region of Portugal. In this way, it is possible to raise the potential of the country's marine resources and the development of differentiating activities in the blue economy to an international scale, contributing to local economic development. In addition, through partnerships with universities, it contributes to the advancement of scientific knowledge, having collaborated on seven master's theses already completed at the company, two doctoral theses completed and another five in progress.

Promoter website

https://sea4us.pt/en/

Team

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Business Model

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